Group 1. Macromolecular complexes (Min Jae Lee)
Sunghoe Chang / Professor, Seoul National University
Research
Opto-physiology, synaptic neurotransmission and structural plasticity. Molecular causative mechanism of neurodegenerative diseases
Opto-physiology, synaptic neurotransmission and structural plasticity. Molecular causative mechanism of neurodegenerative diseases
Publish
18’ Cell Rep 18’ J Clin Invest 17’ Science Signaling 16’ PNAS 15’ Neuron
18’ Cell Rep 18’ J Clin Invest 17’ Science Signaling 16’ PNAS 15’ Neuron
Field
Regulation of intersynaptic signaling and homeostatic plasticity in CNS
Regulation of intersynaptic signaling and homeostatic plasticity in CNS
Youn Soo Choi / Associate Prof., Seoul National University
Research
Protein homeostasis and degradation in the regulation of adaptive immunity
Protein homeostasis and degradation in the regulation of adaptive immunity
Publish
19’ Neurol Neuroimmunol Neuroinflamm 19’ Int. J. Mol. Sci, 18’ Nat Commun, 17’ Nat Commun, 15’ Nat Immunol
19’ Neurol Neuroimmunol Neuroinflamm 19’ Int. J. Mol. Sci, 18’ Nat Commun, 17’ Nat Commun, 15’ Nat Immunol
Field
Protein degradation in the regulation of T dependent humoral immune responses
Protein degradation in the regulation of T dependent humoral immune responses
Yang-Sook Chun / Professor, Seoul National University
Research
Protein degradation regulated by neddylation and ubiquitination-proteasome pathway
Protein degradation regulated by neddylation and ubiquitination-proteasome pathway
Publish
19’ EMBO Reports 15’, 19’ Oncogene 14’ Cell Research 16’ Pharmacol. Research 16’ Cell Death Differ. 18’ BMC cancer; 16’~19’ 3 Patent Registered (1 US patent)
19’ EMBO Reports 15’, 19’ Oncogene 14’ Cell Research 16’ Pharmacol. Research 16’ Cell Death Differ. 18’ BMC cancer; 16’~19’ 3 Patent Registered (1 US patent)
Field
Protein neddylation and its implication in human diseases
Protein neddylation and its implication in human diseases
Hang-Rae Kim / Professor, Seoul National University
Research
CD8 T-cell biology in healthy and tumor environment to identify clues that reflect the clinical benefit of therapy.
CD8 T-cell biology in healthy and tumor environment to identify clues that reflect the clinical benefit of therapy.
Publish
19’ ACS Appl Mater Interface 17’, 19’ Ad Funct.Mat. 17’ Front. Immunol. 19’ Sci Rep.; 8 registered patents and 4 filled patents
19’ ACS Appl Mater Interface 17’, 19’ Ad Funct.Mat. 17’ Front. Immunol. 19’ Sci Rep.; 8 registered patents and 4 filled patents
Field
Identify unknown factors and mechanism affecting the immune system and ultimately contributes to its clinical use for disease prevention and therapy.
Identify unknown factors and mechanism affecting the immune system and ultimately contributes to its clinical use for disease prevention and therapy.
Myoung-Hwan Kim / Associate Prof., Seoul National University
Research
Neurological and psychiatric disorders in the inheritable metabolic diseases.
Neurological and psychiatric disorders in the inheritable metabolic diseases.
Publish
17’, 18’ Neuropharmacology 18’ Genes Brain Behav 18’ J Neurosci
17’, 18’ Neuropharmacology 18’ Genes Brain Behav 18’ J Neurosci
Field
Neurophysiology of brain dysfunction caused by accumulation of toxic metabolite
Neurophysiology of brain dysfunction caused by accumulation of toxic metabolite
Min Jae Lee / Associate Prof., Seoul National University
Research
Protein homeostasis and degradation by regulation of ubiquitin-proteasome system
Protein homeostasis and degradation by regulation of ubiquitin-proteasome system
Publish
16’, 19’ Autophagy 18’ Cell Rep 18’ Angew Chem Int Ed Engl 14’, 16’, 17’ Nat Comm
16’, 19’ Autophagy 18’ Cell Rep 18’ Angew Chem Int Ed Engl 14’, 16’, 17’ Nat Comm
Field
Identify key components of the protein quality control system for the regulation of ubiquitination of proteasome and macromolecular protein complexes
Identify key components of the protein quality control system for the regulation of ubiquitination of proteasome and macromolecular protein complexes
Yong-Seok Lee / Associate Prof., Seoul National University
Research
Translational and post-translational regulation mechanisms involved in synaptic plasticity and learning and memory
Translational and post-translational regulation mechanisms involved in synaptic plasticity and learning and memory
Publish
14’ Nat Neurosci 16’ J Neurosci 17’ Neuropharmacology 19’ Sci Signal
14’ Nat Neurosci 16’ J Neurosci 17’ Neuropharmacology 19’ Sci Signal
Field
Memory enhancing strategy by enhancing plasticity through manipulating protein homeostasis machinery in mouse brain
Memory enhancing strategy by enhancing plasticity through manipulating protein homeostasis machinery in mouse brain
Young Ho Suh / Associate Prof., Seoul National University
Research
Receptor function and homeostasis regulated by stability and degradation of protein/RNA
Receptor function and homeostasis regulated by stability and degradation of protein/RNA
Publish
19’ Elife 17’ J Hepatol. 16’ Neuropharmacology 15’ Nat Commun.
19’ Elife 17’ J Hepatol. 16’ Neuropharmacology 15’ Nat Commun.
Field
Molecular mechanisms of protein/RNA complex degradation and its implication in ALS
Molecular mechanisms of protein/RNA complex degradation and its implication in ALS
Hong-Duk Youn / Professor, Seoul National University
Research
Epigenetic regulation of stemness on embryonic stem cells and cancer cells
Epigenetic regulation of stemness on embryonic stem cells and cancer cells
Publish
16’ Cell Metabolism 18’a, 18’b Nulceic Acids Res. 16’ E-Life, 15’a, 15’b Stem Cells
16’ Cell Metabolism 18’a, 18’b Nulceic Acids Res. 16’ E-Life, 15’a, 15’b Stem Cells
Field
Investigate how metabolism affects epigenetic state during ESC differentiation
Investigate how metabolism affects epigenetic state during ESC differentiation
