Group 3. Diseases of Interest (Inhee Mook-Jung)
Murim Choi / Associate Prof., Seoul National University
Research
Disease-associated genomic variants and their mechanistic links with the human pathology, and clues to benefit patient treatment strategy
Disease-associated genomic variants and their mechanistic links with the human pathology, and clues to benefit patient treatment strategy
Publish
19’ EMBO J. 18’ Nat Commun. 17’, 19’ Am J Hum Genet. 18’ Nat Genet. 17’ Ann Neurol.
19’ EMBO J. 18’ Nat Commun. 17’, 19’ Am J Hum Genet. 18’ Nat Genet. 17’ Ann Neurol.
Field
Identify human gene variants related with degradation process and reveal their functional consequences
Identify human gene variants related with degradation process and reveal their functional consequences
Jin Ho Chung / Professor, Seoul National University
Research
Pathophysiology of skin aging and photoaging; Role of skin-derived factors on health
Pathophysiology of skin aging and photoaging; Role of skin-derived factors on health
Publish
17’a, 17’b, 17’c, 19’ J Invest Dermatol.
17’a, 17’b, 17’c, 19’ J Invest Dermatol.
Field
Investigation and identify skin-derived factors which can improve and prevent degenerative diseases in human
Investigation and identify skin-derived factors which can improve and prevent degenerative diseases in human
Buhm Han / Associate Prof., Seoul National University
Research
Developing algorithms and software packages that contribute to the genomics and bioinformatics research communities to understand of the relationship between genetic variation and traits
Developing algorithms and software packages that contribute to the genomics and bioinformatics research communities to understand of the relationship between genetic variation and traits
Publish
14’, 16’, 18’, 19’ Hum Mol Genet. 19’ Genome Biol. 14’, 15’, 16’ Am J Hum Genet. 16’ Nat Genet.
14’, 16’, 18’, 19’ Hum Mol Genet. 19’ Genome Biol. 14’, 15’, 16’ Am J Hum Genet. 16’ Nat Genet.
Field
To apply algorithms and software using large scale genetic and proteomic database related with degradation molecules to understand macroscopic degradation processes and human disorders.
To apply algorithms and software using large scale genetic and proteomic database related with degradation molecules to understand macroscopic degradation processes and human disorders.
Keon Wook Kang / Professor, Seoul National University
Research
Molecular imaging and nanomedicine
Molecular imaging and nanomedicine
Publish
19’a,19’b Theranostics 17’a, 17’b Eur J Nucl Med Mol Imaging; 4 registered patents
19’a,19’b Theranostics 17’a, 17’b Eur J Nucl Med Mol Imaging; 4 registered patents
Field
In vivo molecular imaging of protein ubiquitination and apoptosis
In vivo molecular imaging of protein ubiquitination and apoptosis
Manho Kim / Professor, Seoul National University
Research
Stem cell-based cell therapy for neurodegeneration such as Huntington’s disease
Stem cell-based cell therapy for neurodegeneration such as Huntington’s disease
Publish
12’, 17’, 19’ Ann Neurol. 18’, 19’, 20’ Ann Clin Transl Neurol. 18’ JAMA Neurol.
12’, 17’, 19’ Ann Neurol. 18’, 19’, 20’ Ann Clin Transl Neurol. 18’ JAMA Neurol.
Field
To develop stem cell-based therapeutic strategies for neurodegenerative disorders
To develop stem cell-based therapeutic strategies for neurodegenerative disorders
Youngsoo Kim / Professor, Seoul National University
Research
Functional Characterization of Biological Pathways using Proteomics Methods. Development of Disease Biomarkers & Multi-marker Panel by Targeted Quantitative Proteomics.
Functional Characterization of Biological Pathways using Proteomics Methods. Development of Disease Biomarkers & Multi-marker Panel by Targeted Quantitative Proteomics.
Publish
18’ Clin Chem 17’, 18’ Mol Cell Proteomics 14’ PNAS 14’ Nat Methods 07’~19’ 65 Patent Applications 15’~19’ 32 Patent Registrations including 8 International Patents (3 Europe; 3 USA; 1 Japan, 1 China)
18’ Clin Chem 17’, 18’ Mol Cell Proteomics 14’ PNAS 14’ Nat Methods 07’~19’ 65 Patent Applications 15’~19’ 32 Patent Registrations including 8 International Patents (3 Europe; 3 USA; 1 Japan, 1 China)
Field
Identify Signaling Pathways and Target Proteins Involved in Degradation Processes and Related Diseases using Targeted & Quantitative Proteomics Techniques.
Identify Signaling Pathways and Target Proteins Involved in Degradation Processes and Related Diseases using Targeted & Quantitative Proteomics Techniques.
Obin Kwon / Assistant Prof., Seoul National University
Research
To elucidate unknown pathophysiology in metabolic and neuropsychiatric disorders and discover novel therapeutic targets
To elucidate unknown pathophysiology in metabolic and neuropsychiatric disorders and discover novel therapeutic targets
Publish
18’ Nat Rev Endocrinol. 18’ Cell Rep. 15’ Autophagy 15’ Nat Neurosci.
18’ Nat Rev Endocrinol. 18’ Cell Rep. 15’ Autophagy 15’ Nat Neurosci.
Field
Develop therapeutic targets for metabolic disorders - diabetes, obesity, and NASH
Develop therapeutic targets for metabolic disorders - diabetes, obesity, and NASH
Seung-Jae Lee / Professor, Seoul National University
Research
Abnormal protein aggregations and their roles in neurodegeneration
Abnormal protein aggregations and their roles in neurodegeneration
Publish
14’, 18’, 19’ Nat Commun 19’ Brain 19’ J Clin Invest 16’ Autopagy 15’ Nature
14’, 18’, 19’ Nat Commun 19’ Brain 19’ J Clin Invest 16’ Autopagy 15’ Nature
Field
To investigate the degradation mechanisms of protein aggregates, and develop diagnostics and therapeutics related with pre-symptomatic neurodegeneration.
To investigate the degradation mechanisms of protein aggregates, and develop diagnostics and therapeutics related with pre-symptomatic neurodegeneration.
Inhee Mook-Jung / Professor, Seoul National University
Research
Pathophysiologic mechanisms of Alzheimer’s disease
Pathophysiologic mechanisms of Alzheimer’s disease
Publish
19’ Cell Metab. 17’, 19’ Nat Commun. 19’ Angew Chem Int Ed Engl 16’, 18’ Autophagy
19’ Cell Metab. 17’, 19’ Nat Commun. 19’ Angew Chem Int Ed Engl 16’, 18’ Autophagy
Field
To investigate the mechanism how defects of protein degradation processes cause the development of Alzheimer’s disease and invent therapeutic targets and tools based on the degradation processes related with neurodegenerative disorders.
To investigate the mechanism how defects of protein degradation processes cause the development of Alzheimer’s disease and invent therapeutic targets and tools based on the degradation processes related with neurodegenerative disorders.
